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Contact Applaud Medical using this form.

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Address

2325 3rd Street, Suite 215
San Francisco, CA, 94107

Email

info@applaudmedical.com

Phone

415-761-1097

Our Technology

The Problem: Kidney Stones are Common and Debilitating

Kidney stones are responsible for more than two million ER visits per year in the U.S. On average, approximately 500,000 laser lithotripsy procedures are completed every year, consuming valuable OR time and money. Unfortunately, many patients wait at home to pass their stone pending over-burdened OR scheduling, leaning on opioids, battling excruciating pain, and increasing the risk of long-term kidney damage, infection and other complications. This can often lead to recurring ER visits, significant financial toxicity and a diminished quality of life.
If a patient is eventually scheduled for a procedure, they are subject to long wait times, multiple exposures to fluoroscopy, general anesthesia for the procedure and, typically, long-distance travel to a major city to get the care they need. The current standard of care for treating kidney stone disease is inadequate.

The Problem: Kidney Stones are Common and Debilitating

Kidney stones are responsible for more than two million ER visits per year in the U.S. On average, approximately 500,000 laser lithotripsy procedures are completed every year, consuming valuable OR time and money. Unfortunately, many patients wait at home to pass their stone pending over-burdened OR scheduling, leaning on opioids, battling excruciating pain, and increasing the risk of long-term kidney damage, infection and other complications. This can often lead to recurring ER visits, significant financial toxicity and a diminished quality of life.

If a patient is eventually scheduled for a procedure, they are subject to long wait times, multiple exposures to fluoroscopy, general anesthesia for the procedure and, typically, long-distance travel to a major city to get the care they need. The current standard of care for treating kidney stone disease is inadequate.

The Brio System: A Powerful New Method Designed to Eliminate Kidney Stones

Applaud Medical’s patented technology is designed to revolutionize kidney stone treatment, eliminating long wait-times and OR procedures, bringing rapid relief to a convenient office setting hours after diagnosis. Acoustically enhanced lithotripsy uses a high-margin and insurance reimbursable single use procedure kit. Quick and easy treatment becomes available to applicable patients who need it. An advanced single-use ureteral beacon catheter designed to locate the stone, delivers microbubble cavitation enhancer and guides low-pressure external ultrasound for lithiasis.

The small BRIO console integrates a hand-held treatment head that aims low-pressure ultrasound through the skin. The locating ureteral beacon catheter is designed to ensure the beam alignment with the stone. The BRIO System catheter is designed to facilitate patented microbubble acoustic enhancement to enable office-based procedures, eliminating the costs and risks associated with intra-operative fluoroscopy or general anesthesia.

Acoustically Enhanced Microbubbles with External Ultrasound

Applaud’s Medical’s acoustically enhanced microbubbles can also be used with externally applied, low pressure ultrasound produced by the BRIO System console to capture acoustic energy.  When exposed to this external ultrasound, the microbubbles expand, collapse and cause cavitation which fragments the stone.

The BRIO System uses Applaud Medical’s proprietary low pressure ultrasound signature to treat smaller stones that have entered and become stuck in the ureter. This treatment method is designed to be carried out in the urologist’s office without anesthesia or imaging to provide relief to many patients who are normally sent home with narcotics and asked to wait days or weeks for the stone to pass naturally.

 

Acoustically Enhanced Microbubbles with URS-LL

When subjected to acoustic impulses from Ureteroscopy Laser Lithotripsy (URS-LL) or other therapies, Applaud Medical’s acoustically enhanced microbubbles produce rapid, large‐amplitude expansions and contractions, then a final collapse. This collapse near a hard surface triggers inertial cavitation, which causes erosion and fragmentation of the stone. The video on the right is recorded from a URS-LL procedure with Applaud’s acoustically enhanced microbubbles in a human subject.
The optical fiber is seen directing the laser light at the kidney stone. The acoustically enhanced microbubbles are visible as a milky cloud in the first few seconds of the video. At the 6th second, the laser begins to activate the fragmentation process, causing the formation and collapse of vapor bubbles to fragment the stone at the tip of the optical fiber. In parallel, our acoustically enhanced microbubbles are capturing energy from the laser and causing cavitation and fragmentation on all other surfaces of the stone, and on fragments as they move away from the optical fiber. The result is faster fragmentation, fewer and smaller fragments and better outcomes.

The high-speed microscope video on the left shows one side of an artificial kidney stone with Applaud Medical’s acoustically enhanced microbubbles all over the surface.  An optical fiber from a pulsed laser is pointed at the opposite side, as would be the case during a normal URS-LL procedure.  When the laser pulse forms a vapor bubble that expands and collapses on the opposite side, our acoustically enhanced microbubbles positioned all over all surfaces of the stone also expand and collapse, causing cavitation and erosion.

In this case, we see that laser pulses targeting one side of a kidney stone can excite our acoustically enhanced microbubbles on the opposite side of the stone and can cause cavitation and erosion.

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